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prs-ms-shtrim21  (OriGene)


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    OriGene prs-ms-shtrim21
    Prs Ms Shtrim21, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/prs-ms-shtrim21/product/OriGene
    Average 90 stars, based on 1 article reviews
    prs-ms-shtrim21 - by Bioz Stars, 2026-04
    90/100 stars

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    prs-ms-shtrim21  (OriGene)
    90
    OriGene prs-ms-shtrim21
    Prs Ms Shtrim21, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/prs-ms-shtrim21/product/OriGene
    Average 90 stars, based on 1 article reviews
    prs-ms-shtrim21 - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    prs ms shtrim21  (OriGene)
    93
    OriGene prs ms shtrim21
    ( A ) Immunostaining using anti-TRIM21 in liver sections from <t>Ad-shTrim21</t> or Ad-Ctrl C57BL/6N mice fed a NASH diet for 30 weeks. ( B and C ) Relative hepatic mRNA expression of Trim21 ( B ), and A1cf and Khk ( C ). ( D ) Western blot analysis of indicated proteins ( n = 3 mice per group). ( E – I ) Liver weight ( E ), ratios of liver/body weight ( F ), liver TG ( G ), H&E and Oil Red O staining of liver sections ( H ), and immunoblot analysis of indicated lipogenesis genes ( I ) ( n = 3 mice per group) from mice indicated as in A . ( J–N ) Endogenous ubiquitination of SREBP1 ( J ), ChREBP ( K ), ACC ( L ), FASN ( M ), and A1CF ( N ) from liver extracts from mice indicated as in A ( n = 2). ( O ) Relative mRNA expression of de novo lipogenesis and glycolysis genes from mice indicated as in A . Scale bars: 50 μm. n represents number of replicates, 1 mouse/replicate. In all statistical plots, data are expressed as the mean ± SD; **** P < 0.0001; *** P < 0.001; ** P < 0.01; * P < 0.05. Statistical analysis for B , C , E–G , and O were carried out by 1-way ANOVA with Sidak’s post hoc analysis, n = 6 mice per group.
    Prs Ms Shtrim21, supplied by OriGene, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/prs ms shtrim21/product/OriGene
    Average 93 stars, based on 1 article reviews
    prs ms shtrim21 - by Bioz Stars, 2026-04
    93/100 stars
    		  Buy from Supplier

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    ( A ) Immunostaining using anti-TRIM21 in liver sections from Ad-shTrim21 or Ad-Ctrl C57BL/6N mice fed a NASH diet for 30 weeks. ( B and C ) Relative hepatic mRNA expression of Trim21 ( B ), and A1cf and Khk ( C ). ( D ) Western blot analysis of indicated proteins ( n = 3 mice per group). ( E – I ) Liver weight ( E ), ratios of liver/body weight ( F ), liver TG ( G ), H&E and Oil Red O staining of liver sections ( H ), and immunoblot analysis of indicated lipogenesis genes ( I ) ( n = 3 mice per group) from mice indicated as in A . ( J–N ) Endogenous ubiquitination of SREBP1 ( J ), ChREBP ( K ), ACC ( L ), FASN ( M ), and A1CF ( N ) from liver extracts from mice indicated as in A ( n = 2). ( O ) Relative mRNA expression of de novo lipogenesis and glycolysis genes from mice indicated as in A . Scale bars: 50 μm. n represents number of replicates, 1 mouse/replicate. In all statistical plots, data are expressed as the mean ± SD; **** P < 0.0001; *** P < 0.001; ** P < 0.01; * P < 0.05. Statistical analysis for B , C , E–G , and O were carried out by 1-way ANOVA with Sidak’s post hoc analysis, n = 6 mice per group.

    Journal: JCI Insight

    Article Title: Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators

    doi: 10.1172/jci.insight.164694

    Figure Lengend Snippet: ( A ) Immunostaining using anti-TRIM21 in liver sections from Ad-shTrim21 or Ad-Ctrl C57BL/6N mice fed a NASH diet for 30 weeks. ( B and C ) Relative hepatic mRNA expression of Trim21 ( B ), and A1cf and Khk ( C ). ( D ) Western blot analysis of indicated proteins ( n = 3 mice per group). ( E – I ) Liver weight ( E ), ratios of liver/body weight ( F ), liver TG ( G ), H&E and Oil Red O staining of liver sections ( H ), and immunoblot analysis of indicated lipogenesis genes ( I ) ( n = 3 mice per group) from mice indicated as in A . ( J–N ) Endogenous ubiquitination of SREBP1 ( J ), ChREBP ( K ), ACC ( L ), FASN ( M ), and A1CF ( N ) from liver extracts from mice indicated as in A ( n = 2). ( O ) Relative mRNA expression of de novo lipogenesis and glycolysis genes from mice indicated as in A . Scale bars: 50 μm. n represents number of replicates, 1 mouse/replicate. In all statistical plots, data are expressed as the mean ± SD; **** P < 0.0001; *** P < 0.001; ** P < 0.01; * P < 0.05. Statistical analysis for B , C , E–G , and O were carried out by 1-way ANOVA with Sidak’s post hoc analysis, n = 6 mice per group.

    Article Snippet: The plasmids included: pLenti-msA1CF-Myc–expressing mouse A1CF (NM_001081074) tagged with Myc (MR224176L1), pRS-ms-shTRIM21 (TR514859), and the PCMV6-huTRIM21-expressing human TRIM21 cDNA (NM_003141) tagged by Myc (RC202088), provided by Origene.

    Techniques: Immunostaining, Expressing, Western Blot, Staining